Department of Coronary Artery Disease, Heart Center, First Clinical Medical College and First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, P.R. China.
Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, P.R. China.
Biosci Rep. 2018 Nov 28;38(6). doi: 10.1042/BSR20181696. Print 2018 Dec 21.
Selenoprotein S (SelS) gene expression is positively correlated to triglyceride (TG) concentrations and is associated with diabetes in animal model. However, the relationship between genetic polymorphisms of SelS and Type 2 diabetes (T2DM) remains unclear. In the present study, we genotyped four single nucleotide polymorphisms (rs12910524, rs1384565, rs2101171, rs4965814) of gene using TaqMan genotyping method in a case-control study (1947 T2DM patients and 1639 control subjects). We found both rs1384565 CC genotype (12.1 compared with 6.6%, <0.001) and C allele (35.2 compared with 24.4%, <0.001) were more frequent in the T2DM patients than in the controls. Logistic regression analysis suggested after adjustment of other confounders, the difference remained significant between the two groups (CC compared with TT, =0.002, OR = 1.884, 95% CI: 1.263-2.811; CT compared with TT, <0.001, OR = 1.764, 95% CI: 1.412-2.204). The present study suggested that genetic polymorphisms of SelS were associated with T2DM in a Chinese population.
硒蛋白 S（SelS）基因表达与甘油三酯（TG）浓度呈正相关，并且与动物模型中的糖尿病有关。然而，SelS 基因的遗传多态性与 2 型糖尿病（T2DM）之间的关系尚不清楚。在本研究中，我们使用 TaqMan 基因分型方法在病例对照研究（1947 例 T2DM 患者和 1639 例对照）中对基因的四个单核苷酸多态性（rs12910524、rs1384565、rs2101171、rs4965814）进行了基因分型。我们发现 rs1384565CC 基因型（12.1%比 6.6%，<0.001）和 C 等位基因（35.2%比 24.4%，<0.001）在 T2DM 患者中比对照组更为常见。Logistic 回归分析表明，在调整其他混杂因素后，两组之间的差异仍然显著（CC 与 TT 相比，=0.002，OR=1.884，95%CI：1.263-2.811；CT 与 TT 相比，<0.001，OR=1.764，95%CI：1.412-2.204）。本研究表明，SelS 基因的遗传多态性与中国人群的 T2DM 相关。
