Messler H H, Koch W, Münzenberg K J
Orthopedic Hospital, University of Bonn, Federal Republic of Germany.
Clin Orthop Relat Res. 1990 Sep(258):135-41.
High doses of both calcium antagonists and magnesium lead to disorders in the early phase of calcification. Analogous to known mechanisms of calcification outside the bone, the calcium overload of cellular suborganelles, which may play a role in enchondral ossification, is assumed to be prevented or delayed by calcium antagonists and magnesium. In accordance with the relevant literature, which describes analogous cytoprotective effects of calcium antagonists and magnesium in association with extraskeletal calcification and ossification, the qualitative agreement of histologic findings in the epiphyseal growth plate suggests a homologous, primarily intracellular mechanism of action of both magnesium and organic calcium antagonists. This common mechanism of action of the two substances on the molar Mg-Ca quotient, with reference to intracellular calcium phosphate mineralization, is regarded as the cause of the analogous effects.
高剂量的钙拮抗剂和镁都会在钙化早期导致紊乱。类似于已知的骨外钙化机制，细胞亚细胞器的钙超载可能在软骨内骨化中起作用，据推测钙拮抗剂和镁可预防或延缓这种情况。根据相关文献描述，钙拮抗剂和镁在骨外钙化和骨化方面具有类似的细胞保护作用，骨骺生长板组织学结果的定性一致性表明镁和有机钙拮抗剂具有同源的、主要是细胞内的作用机制。这两种物质对摩尔镁钙商的共同作用机制，涉及细胞内磷酸钙矿化，被认为是产生类似效应的原因。
