Pavić Ivica, Cekinović Durdica, Begovac Josip, Maretić Tomislav, Civljak Rok, Troselj-Vukić Biserka
University of Rijeka, Rijeka University Hospital Center, Clinic for Infectious Diseases, Rijeka, Croatia.
Coll Antropol. 2013 Jun;37(2):619-23.
Cryptococcus neoformans is a leading cause of invasive cryptoccocal infections which include meningitis/meningoencephalitis, cerebral cryptococcoma, invasive pulmonary and mediastinal infection. Invasive infection is mainly diagnosed in immunocompromised patients, especially in HIV-infected individuals. There is a rising number of patients with invasive cryptococcal infections in immunocompromised patients who are HIV-negative. Among several primary immunodeficiency syndromes, considered as possible reasons for these invasive infections, idiopathic CD4+ T lymphocytopenia (ICL) is most frequently diagnosed. The pathogenesis of this rare syndrome is still unknown, while its clinical spectrum ranges from an asymptomatic laboratory abnormality to life-threatening opportunistic infections. Here we present an HIV-negative young man suffering from cryptococcal meningoencephalitis in whom ICL was diagnosed.
新型隐球菌是侵袭性隐球菌感染的主要病因，侵袭性隐球菌感染包括脑膜炎/脑膜脑炎、脑隐球菌瘤、侵袭性肺和纵隔感染。侵袭性感染主要在免疫功能低下的患者中被诊断出来，尤其是在感染HIV的个体中。在HIV阴性的免疫功能低下患者中，侵袭性隐球菌感染的患者数量正在上升。在几种被认为是这些侵袭性感染可能原因的原发性免疫缺陷综合征中，特发性CD4+T淋巴细胞减少症（ICL）是最常被诊断出的。这种罕见综合征的发病机制仍然未知，而其临床谱从无症状的实验室异常到危及生命的机会性感染不等。在此，我们报告一名患有隐球菌性脑膜脑炎的HIV阴性青年男性，该患者被诊断为ICL。
