Brysch W, Brysch I, Creutzfeldt O D, Schlingensiepen R, Schlingensiepen K H
Abteilung Neurobiologie, Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Federal Republic of Germany.
Exp Brain Res. 1990;81(1):1-17. doi: 10.1007/BF00230095.
This paper addresses the question of a general topological principle of thalamo-cortical projections. In the lissencephalic primate brain of the common marmoset (Callithrix jacchus), large injections of horseradish peroxidase were made in various parts of the neocortex. These injections were placed in different animals and hemispheres along various caudo-rostral and medio-lateral gradients. Labelled cells in the thalamus were plotted and the labelling-zones resulting from several injections along a medio-lateral and two caudo-rostral cortical vectors were drawn into semi-schematic thalamic maps. These composite maps reveal a topological organization of the whole thalamo-cortical projection. The thalamic representation of the caudo-rostral and medio-lateral gradients indicate a rotation of the posterior relative to the anterior thalamus. An attempt is made to relate the organization of the thalamo-cortical projection to the development of the thalamus and the cortex. The cortex is divided into concentric zones around the sensory-motor and insular cortex. The thalamus is divided into corresponding projection zones. The topology of thalamo-cortical connections can then be regarded as a consequence of corresponding thalamic and cortical growth gradients. This is not only consistent with the general thalamo-cortical topology and the inversion of maps from thalamus to cortex, but also explains the continuity and overlap of thalamic projection zones in the pulvinar to widely separated cortical areas as the parietal, temporal and frontal association cortex.
本文探讨了丘脑 - 皮质投射的一般拓扑学原理问题。在普通狨猴（Callithrix jacchus）的光滑脑灵长类动物大脑中，在新皮质的不同部位进行了大量辣根过氧化物酶注射。这些注射沿着不同的尾 - 嘴侧和中 - 外侧梯度分别注射到不同的动物和半球中。绘制了丘脑中的标记细胞，并将沿着中 - 外侧和两个尾 - 嘴侧皮质向量的多次注射所产生的标记区域绘制到半示意性丘脑图谱中。这些复合图谱揭示了整个丘脑 - 皮质投射的拓扑组织。尾 - 嘴侧和中 - 外侧梯度的丘脑表征表明后丘脑相对于前丘脑发生了旋转。本文试图将丘脑 - 皮质投射的组织与丘脑和皮质的发育联系起来。皮质围绕感觉运动皮质和岛叶皮质分为同心区域。丘脑被分为相应的投射区域。丘脑 - 皮质连接的拓扑结构可被视为相应的丘脑和皮质生长梯度的结果。这不仅与一般的丘脑 - 皮质拓扑结构以及从丘脑到皮质的图谱倒置相一致，还解释了丘脑枕叶投射区域与广泛分离的皮质区域（如顶叶、颞叶和额叶联合皮质）之间的连续性和重叠。
