Department of Microbiology, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701-0192, Japan,
J Neurovirol. 2014 Apr;20(2):164-74. doi: 10.1007/s13365-013-0192-8. Epub 2013 Aug 14.
Human T cell leukemia virus type 1 (HTLV-1) is a human retrovirus etiologically associated with adult T cell leukemia/lymphoma and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only approximately 0.25-4 % of infected individuals develop HAM/TSP; the majority of infected individuals remain lifelong asymptomatic carriers. Recent data suggest that immunological aspects of host-virus interactions might play an important role in the development and pathogenesis of HAM/TSP. This review outlines and discusses the current understanding, ongoing developments, and future perspectives of HAM/TSP research.
人类 T 细胞白血病病毒 1 型（HTLV-1）是一种人类逆转录病毒，与成人 T 细胞白血病/淋巴瘤和 HTLV-1 相关的脊髓病/热带痉挛性截瘫（HAM/TSP）有关。只有约 0.25-4%的感染者会发展为 HAM/TSP；大多数感染者终身无症状携带。最近的数据表明，宿主-病毒相互作用的免疫学方面可能在 HAM/TSP 的发展和发病机制中发挥重要作用。本文概述并讨论了 HAM/TSP 研究的当前认识、正在进行的发展和未来展望。
