抗菌类肽的合成。

Synthesis of antimicrobial peptoids.

作者信息

Hansen Paul R, Munk Jens K

机构信息

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

出版信息

Methods Mol Biol. 2013;1047:151-9. doi: 10.1007/978-1-62703-544-6_11.

DOI:10.1007/978-1-62703-544-6_11

PMID:23943485

Abstract

Peptoids (N-substituted glycines) are mimics of α-peptides in which the side chains are attached to the backbone N (α) -amide nitrogen instead of the C (α) -atom. Peptoids hold promise as therapeutics since they often retain the biological activity of the parent peptide and are stable to proteases. In recent years, peptoids have attracted attention as new potential antibiotics against multiresistant bacteria. Here we describe the submonomer solid-phase synthesis of an antimicrobial peptoid, H-Nmbn-Nlys-Nlys-Nnap-Nbut-Nmbn-Nlys-NH2.

摘要

类肽（N-取代甘氨酸）是α-肽的模拟物，其中侧链连接在主链的N（α）-酰胺氮上，而非C（α）原子。类肽有望成为治疗药物，因为它们通常保留母体肽的生物活性，并且对蛋白酶稳定。近年来，类肽作为对抗多重耐药菌的新型潜在抗生素受到关注。在此，我们描述了一种抗菌类肽H-Nmbn-Nlys-Nlys-Nnap-Nbut-Nmbn-Nlys-NH2的亚单体固相合成。