Stawikowski Maciej J
Torrey Pines Institute for Molecular Studies, Port St. Lucie, FL, USA.
Methods Mol Biol. 2013;1081:47-60. doi: 10.1007/978-1-62703-652-8_4.
Peptoids (oligomers of N-substituted glycine residues) and peptide-peptoid hybrid polymers (peptomers) are interesting classes of compounds mimicking structure and function of biologically active peptides. The oligomeric peptidomimetics such as peptoids are particularly important compounds since they provide access to an enormous molecular diversity, by variation of the building blocks. The modular structure of peptoids, ease of synthesis, and high compatibility with existing peptide chemistry synthetic protocols, make peptoids and peptoid-containing peptidomimetics ideal tools for structure-activity and drug discovery related studies.
类肽（N-取代甘氨酸残基的低聚物）和肽-类肽杂合聚合物（肽聚物）是模拟生物活性肽结构和功能的有趣化合物类别。诸如类肽之类的低聚肽模拟物是特别重要的化合物，因为通过改变构建单元，它们能够实现巨大的分子多样性。类肽的模块化结构、易于合成以及与现有肽化学合成方案的高度兼容性，使得类肽和含类肽的肽模拟物成为结构活性和药物发现相关研究的理想工具。
