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单线态氧敏近红外荧光多模态纳米粒子。

Singlet-oxygen-sensitizing near-infrared-fluorescent multimodal nanoparticles.

机构信息

Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa 761-0395 (Japan); PRESTO (Japan) Science and Technology Agency (JST) (Japan).

出版信息

Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10559-63. doi: 10.1002/anie.201304264. Epub 2013 Aug 13.

DOI:10.1002/anie.201304264
PMID:23943605
Abstract

Nanoprobes based on quantum clusters (QC) with near-infrared fluorescence, magnetic-resonance-imaging contrast, and singlet-oxygen-sensitized intracellular fluorescence are studied. The generation of singlet oxygen and singlet-oxygen-sensitized fluorescence uncaging by magnetic and NIR-emitting nanoparticles are exploited for multimodal bioimaging in vitro.

摘要

研究了基于具有近红外荧光、磁共振成像对比和单线态氧敏化细胞内荧光的量子点(QC)的纳米探针。利用磁性和近红外发射纳米颗粒产生单线态氧和单线态氧敏化荧光的光解,实现了体外多模态生物成像。

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