Jakubiec-Puka A, Drabikowski W
Enzyme. 1978;23(1):10-21. doi: 10.1159/000458544.
Changes in the proteolytic activity and in the relative content of protein in soluble, myofibrillar and insoluble fractions were investigated following denervation and reinnervation of the soleus and tibialis anterior muscles of the rat. After denervation an increase of autolysis in the acid and neutral pH range, but not in the alkaline one, was found in both muscles. An increased autolysis at the acid and neutral pH range was also observed in both muscles after reinnervation, when the weight of the muscles increased. The results indicate the lack of inverse relationship between the changes of proteolytic activity and the decrease or increase of the amount of muscle protein in the course of muscle atrophy and regeneration.
研究了大鼠比目鱼肌和胫骨前肌去神经支配和重新神经支配后，蛋白水解活性以及可溶性、肌原纤维和不溶性部分蛋白质相对含量的变化。去神经支配后，在酸性和中性pH范围内，而不是碱性范围内，发现两块肌肉的自溶作用均增强。当肌肉重量增加时，重新神经支配后两块肌肉在酸性和中性pH范围内的自溶作用也增强。结果表明，在肌肉萎缩和再生过程中，蛋白水解活性的变化与肌肉蛋白量的减少或增加之间不存在反比关系。
