高效液相色谱-二极管阵列检测/电喷雾离子化-四极杆飞行时间质谱法分析两面针中的生物碱
[Analysis of alkaloids in Zanthoxylum nitidum by HPLC-DAD/ESI-Q-TOF-MS].
作者信息
Jia Chang-Ping, Huang Xue-Li, Li Yun, Feng Fang
机构信息
Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2013 Apr;38(8):1198-202.
The alkaloids in Zanthoxylum nitidum were identified by HPLC-DAD/ESI-Q-TOF-MS. Separation was performed on a Hanbon C18 column with acetonitrile (with 0.1% formic acid) and water(with 0.1% formic acid) as mobile phase. Based on the high-resolution mass information, MS/MS fragmentation behaviors and chemical components from literatures, 48 components were identified or tentatively characterized including 6 new compounds. This work could be useful for the quality control and further studies of the plant.
利用高效液相色谱-二极管阵列检测/电喷雾电离-四极杆-飞行时间质谱（HPLC-DAD/ESI-Q-TOF-MS）对两面针中的生物碱进行了鉴定。采用汉邦C18柱，以乙腈（含0.1%甲酸）和水（含0.1%甲酸）作为流动相进行分离。基于高分辨质谱信息、二级质谱碎裂行为以及文献中的化学成分，共鉴定或初步表征了48种成分，其中包括6种新化合物。该研究可为该植物的质量控制和进一步研究提供参考。
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