Meng Shu, Yang Li-Qun, Ma Li-Ying, Guo Jing, Li Miao, Yang Dan
Liaoning Institute of Family Planning, Shenyang 110031, China.
Zhongguo Zhong Yao Za Zhi. 2013 May;38(9):1371-4.
Ethosomes, as a new vector for transdermal drug delivery, could obviously improve the transdermal penetration of drugs. In this study, we prepared testosterone undecanoate ethosomes, with TU ethosomes as the basic remedy, to determine its appearance, particle size, entrapment efficiency (EE) and membrane fluidity. Meanwhile, a transdermal test was conducted in mice, in order to determine the permeability characteristics of ethosomes as a vector for transdermal drug delivery, and compare transdermal behaviors of TU ethosomes, liposomes and their ethanol solutions.
乙醇脂质体作为一种新型的透皮给药载体，能够显著提高药物的透皮渗透率。在本研究中，我们以十一酸睾酮乙醇脂质体为基础制剂，制备了十一酸睾酮乙醇脂质体，以测定其外观、粒径、包封率（EE）和膜流动性。同时，在小鼠身上进行了透皮试验，以确定乙醇脂质体作为透皮给药载体的渗透特性，并比较十一酸睾酮乙醇脂质体、脂质体及其乙醇溶液的透皮行为。
