组胺药理学：四年进展。
Histamine pharmacology: four years on.
出版信息
Br J Pharmacol. 2013 Sep;170(1):1-3. doi: 10.1111/bph.12319.
Abstract
The histamine field has moved on rapidly in the last four years, with expansion in roles and clinical development, particularly in the newest two of four histamine receptors. This themed volume is a testament to this expansion with 16 original and review articles spanning a wide spectrum of histamine-related topics, with therapeutic translational relevance to addiction, dementias, anxiety disorders, cancers, vestibular disorders, migraine and autoimmune disorders.
摘要
在过去的四年中，组胺领域发展迅速，其作用和临床应用不断扩展，特别是在四个组胺受体中的后两个。本专题卷就是这一扩展的证明，其中包含 16 篇原创和综述文章，涵盖了广泛的与组胺相关的主题，具有治疗转化相关性，涉及成瘾、痴呆、焦虑障碍、癌症、前庭障碍、偏头痛和自身免疫性疾病。
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Histamine pharmacology: four years on.组胺药理学：四年进展。
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Genomics meets histamine receptors: new subtypes, new receptors.
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Therapeutic potential of histaminergic compounds in the treatment of addiction and drug-related cognitive disorders.组胺能化合物在治疗成瘾和与药物相关的认知障碍中的治疗潜力。
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Cherry-picked ligands at histamine receptor subtypes.组胺受体亚型的精选配体。
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Quantitative electrophysiological monitoring of anti-histamine drug effects on live cells via reusable sensor platforms.通过可重复使用的传感器平台对活细胞中的抗组胺药物作用进行定量电生理监测。
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The histaminergic H1, H2, and H3 receptors of the lateral septum differentially mediate the anxiolytic-like effects of histamine on rats' defensive behaviors in the elevated plus maze and novelty-induced suppression of feeding paradigm.外侧隔区的组胺能 H1、H2 和 H3 受体差异调节组胺对大鼠在高架十字迷宫和新异环境抑制摄食模型中防御行为的抗焦虑样作用。
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Histamine Intolerance Originates in the Gut.组胺不耐受源于肠道。
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Antihistamines Modulate Functional Activity of Macrophages.抗组胺药调节巨噬细胞的功能活性。
Bull Exp Biol Med. 2021 Apr;170(6):759-762. doi: 10.1007/s10517-021-05150-2. Epub 2021 Apr 24.
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Procognitive impact of ciproxifan (a histaminergic H receptor antagonist) on contextual memory retrieval after acute stress.西匹福林（一种组胺能 H 受体拮抗剂）对急性应激后情景记忆检索的前认知影响。
CNS Neurosci Ther. 2019 Aug;25(8):832-841. doi: 10.1111/cns.13113. Epub 2019 May 15.
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Histamine H1 Receptor Contributes to Vestibular Compensation.组胺 H1 受体参与前庭代偿。
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Histamine Excites Striatal Dopamine D1 and D2 Receptor-Expressing Neurons via Postsynaptic H1 and H2 Receptors.组胺通过突触后 H1 和 H2 受体兴奋纹状体多巴胺 D1 和 D2 受体表达神经元。
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Granulocytes in Ocular HSV-1 Infection: Opposing Roles of Mast Cells and Neutrophils.眼部单纯疱疹病毒1型感染中的粒细胞：肥大细胞和中性粒细胞的相反作用
Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3763-75. doi: 10.1167/iovs.15-16900.
本文引用的文献
1
Antagonism of histamine H4 receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis.组胺 H4 受体拮抗剂可加重实验性自身免疫性脑脊髓炎的临床和病理征象。
Br J Pharmacol. 2013 Sep;170(1):67-77. doi: 10.1111/bph.12263.
2
A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.胺能 G 蛋白偶联受体的结构化学生物基因组学分析：组胺受体配体设计的启示。
Br J Pharmacol. 2013 Sep;170(1):101-26. doi: 10.1111/bph.12248.
3
A single-point mutation (Ala280Val) in the third intracellular loop alters the signalling properties of the human histamine H₃ receptor stably expressed in CHO-K1 cells.一个单点突变（Ala280Val）在第三细胞内环改变了人组氨酸 H₃ 受体在 CHO-K1 细胞中稳定表达的信号转导特性。
Br J Pharmacol. 2013 Sep;170(1):127-35. doi: 10.1111/bph.12257.
4
Postsynaptic mechanisms underlying the excitatory action of histamine on medial vestibular nucleus neurons in rats.组胺对大鼠前庭神经核神经元兴奋作用的突触后机制。
Br J Pharmacol. 2013 Sep;170(1):156-69. doi: 10.1111/bph.12256.
5
Histamine H₃ receptors, the complex interaction with dopamine and its implications for addiction.组胺 H₃ 受体，与多巴胺的复杂相互作用及其对成瘾的影响。
Br J Pharmacol. 2013 Sep;170(1):46-57. doi: 10.1111/bph.12221.
6
Profiling of histamine H4 receptor agonists in native human monocytes.在原代人单核细胞中鉴定组氨酸 H4 受体激动剂。
Br J Pharmacol. 2013 Sep;170(1):136-43. doi: 10.1111/bph.12237.
7
Influence of the hippocampus on amino acid utilizing and cholinergic neurons within the nucleus accumbens is promoted by histamine via H₁ receptors.组氨酸通过 H₁ 受体促进海马对伏隔核内氨基酸利用和胆碱能神经元的影响。
Br J Pharmacol. 2013 Sep;170(1):170-6. doi: 10.1111/bph.12212.
8
Potential enhancing effects of histamine H₁ agonism/H₃ antagonism on working memory assessed by performance and bold response in healthy volunteers.健康志愿者的工作记忆的性能和 bold 反应评估组胺 H₁激动/H₃拮抗的潜在增强作用。
Br J Pharmacol. 2013 Sep;170(1):144-55. doi: 10.1111/bph.12184.
9
Histamine is required for H₃ receptor-mediated alcohol reward inhibition, but not for alcohol consumption or stimulation.组胺是 H₃ 受体介导的酒精奖赏抑制所必需的，但不是酒精摄入或刺激所必需的。
Br J Pharmacol. 2013 Sep;170(1):177-87. doi: 10.1111/bph.12170.
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Expression of histamine receptor genes Hrh3 and Hrh4 in rat brain endothelial cells.组胺受体基因 Hrh3 和 Hrh4 在大鼠脑内皮细胞中的表达。
Br J Pharmacol. 2013 Sep;170(1):58-66. doi: 10.1111/bph.12173.
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