Ely D L, Turner M E
Department of Biology, University of Akron, Ohio 44325.
Hypertension. 1990 Sep;16(3):277-81. doi: 10.1161/01.hyp.16.3.277.
The objective of our study was to determine the genetic influence on blood pressure in spontaneously hypertensive rats (SHR), and normotensive Wistar-Kyoto (WKY) rats using genetic crosses. Blood pressure was measured by tail sphygmomanometry from 8 to 20 weeks of age. Blood pressure was significantly higher from 12 to 20 weeks in the male offspring derived from WKY mothers x SHR fathers as compared with male offspring derived from SHR mothers X WKY fathers (180 +/- 4 versus 160 +/- 5 mm Hg, p less than 0.01). There was no significant difference between the blood pressure of the F1 females, further supporting Y chromosome linkage and not parental imprinting. The blood pressure data from F2 males derived from reciprocal crosses of parental strains were consistent with the presence of a Y-linked locus, but not with an X-linked locus controlling blood pressure. The data strongly suggest that hypertension in the SHR has two primary components of equal magnitude, one consisting of a small number of autosomal loci with a second Y-linked component.
我们研究的目的是通过遗传杂交来确定基因对自发性高血压大鼠（SHR）和正常血压的Wistar-Kyoto（WKY）大鼠血压的影响。在8至20周龄期间，通过尾动脉血压测量法测量血压。与来自SHR母亲×WKY父亲的雄性后代相比，来自WKY母亲×SHR父亲的雄性后代在12至20周时血压显著更高（180±4对160±5 mmHg，p<0.01）。F1雌性的血压之间没有显著差异，这进一步支持了Y染色体连锁而非亲本印记。来自亲本菌株相互杂交的F2雄性的血压数据与存在Y连锁基因座一致，但与控制血压的X连锁基因座不一致。数据强烈表明，SHR中的高血压有两个同等程度的主要成分，一个由少数常染色体基因座组成，另一个是Y连锁成分。
