Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre , WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre for Education, Gopalapuram, Chennai, India .
Diabetes Technol Ther. 2013 Oct;15(10):897-9. doi: 10.1089/dia.2013.0144. Epub 2013 Aug 14.
Glycated hemoglobin (HbA1c) is the most widely accepted index of long-term glycemic control. However, there are some clinical situations that make the accurate measurement of HbA1c difficult. Although some of these situations are general, others are more specific to some parts of the world like India. These conditions include hemoglobinopathies such as thalassemias and structural hemoglobin (Hb) variants such as HbS and HbD, as well as iron-deficiency anemia and the use of certain drugs. Because of the relatively frequent occurrence of some of these conditions in some parts of India, it is important that they are looked for when evaluating an inappropriately high or low HbA1c level. Alternative indices may have to be used for assessing glycemic control in these cases.
糖化血红蛋白 (HbA1c) 是最广泛接受的长期血糖控制指标。然而，有些临床情况使得 HbA1c 的准确测量变得困难。虽然这些情况有些是普遍的，但有些则更特定于某些地区，如印度。这些情况包括血红蛋白病，如地中海贫血和结构血红蛋白 (Hb) 变体，如 HbS 和 HbD，以及缺铁性贫血和某些药物的使用。由于这些情况在印度的某些地区相对频繁发生，因此在评估 HbA1c 水平不适当升高或降低时，有必要寻找这些情况。在这些情况下，可能需要使用替代指标来评估血糖控制。
