印度糖化血红蛋白评估面临的挑战。
Challenges in estimation of glycated hemoglobin in India.
机构信息
Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre , WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre for Education, Gopalapuram, Chennai, India .
出版信息
Diabetes Technol Ther. 2013 Oct;15(10):897-9. doi: 10.1089/dia.2013.0144. Epub 2013 Aug 14.
Abstract
Glycated hemoglobin (HbA1c) is the most widely accepted index of long-term glycemic control. However, there are some clinical situations that make the accurate measurement of HbA1c difficult. Although some of these situations are general, others are more specific to some parts of the world like India. These conditions include hemoglobinopathies such as thalassemias and structural hemoglobin (Hb) variants such as HbS and HbD, as well as iron-deficiency anemia and the use of certain drugs. Because of the relatively frequent occurrence of some of these conditions in some parts of India, it is important that they are looked for when evaluating an inappropriately high or low HbA1c level. Alternative indices may have to be used for assessing glycemic control in these cases.
摘要
糖化血红蛋白 (HbA1c) 是最广泛接受的长期血糖控制指标。然而，有些临床情况使得 HbA1c 的准确测量变得困难。虽然这些情况有些是普遍的，但有些则更特定于某些地区，如印度。这些情况包括血红蛋白病，如地中海贫血和结构血红蛋白 (Hb) 变体，如 HbS 和 HbD，以及缺铁性贫血和某些药物的使用。由于这些情况在印度的某些地区相对频繁发生，因此在评估 HbA1c 水平不适当升高或降低时，有必要寻找这些情况。在这些情况下，可能需要使用替代指标来评估血糖控制。
相似文献
1
Challenges in estimation of glycated hemoglobin in India.印度糖化血红蛋白评估面临的挑战。
Diabetes Technol Ther. 2013 Oct;15(10):897-9. doi: 10.1089/dia.2013.0144. Epub 2013 Aug 14.
2
Prevalence of hemoglobin variants in a diabetic population at high risk of hemoglobinopathies and optimization of HbA1c monitoring by incorporating HPLC in the laboratory workup.血红蛋白病高风险糖尿病患者群体中血红蛋白变异体的患病率以及通过在实验室检查中纳入高效液相色谱法优化糖化血红蛋白（HbA1c）监测
Libyan J Med. 2014 Oct 27;9(1):25768. doi: 10.3402/ljm.v9.25768. eCollection 2014.
3
Influence of iron deficiency anemia on hemoglobin A1c levels in diabetic individuals with controlled plasma glucose levels.缺铁性贫血对血糖水平得到控制的糖尿病患者糖化血红蛋白水平的影响。
Iran Biomed J. 2014;18(2):88-93. doi: 10.6091/ibj.1257.2014.
4
Correlation of Anemia with Glycated Hemoglobin among Euglycemic Type 2 Diabetic Patients.血糖正常的 2 型糖尿病患者的贫血与糖化血红蛋白的相关性。
J Assoc Physicians India. 2023 Mar;71(3):11-12. doi: 10.5005/japi-11001-0201.
5
Influence of iron metabolism indices on HbA1c in non-diabetic pregnant women with and without iron-deficiency anemia: effect of iron supplementation.铁代谢指标对合并和未合并缺铁性贫血的非糖尿病孕妇糖化血红蛋白（HbA1c）的影响：铁补充剂的作用
Diabetes Metab Syndr. 2012 Apr-Jun;6(2):102-5. doi: 10.1016/j.dsx.2012.05.011. Epub 2012 Jun 28.
6
Inverse Association between Iron Deficiency and Glycated Hemoglobin Levels in Ghanaian Adults-the RODAM Study.加纳成年人缺铁与糖化血红蛋白水平呈负相关-RODAM 研究。
J Nutr. 2020 Jul 1;150(7):1899-1908. doi: 10.1093/jn/nxaa109.
7
Factors Modulating Blood HbA1C Level and Diabetic Retinopathy.调节血液糖化血红蛋白水平和糖尿病视网膜病变的因素
J Assoc Physicians India. 2015 May;63(5):95-6.
8
Thalassemia and iron deficiency in a group of northeast Thai school children: relationship to the occurrence of anemia.一组泰国东北部学童的地中海贫血症和缺铁症：与贫血症发生的关系。
Eur J Pediatr. 2010 Nov;169(11):1317-22. doi: 10.1007/s00431-010-1218-3. Epub 2010 May 19.
9
Incidence of hemoglobinopathies and thalassemias in Northern Alberta. Establishment of reference intervals for HbF and HbA2.加拿大艾伯塔省北部血红蛋白病和地中海贫血的发病率。HbF和HbA2参考区间的建立。
Clin Biochem. 2015 Jul;48(10-11):698-702. doi: 10.1016/j.clinbiochem.2015.04.001. Epub 2015 Apr 11.
10
Clinical impact of glycated albumin as another glycemic control marker.糖化白蛋白作为另一种血糖控制标志物的临床影响。
Endocr J. 2010;57(9):751-62. doi: 10.1507/endocrj.k10e-138. Epub 2010 Aug 17.
引用本文的文献
1
Prevalence, awareness, treatment, and control of diabetes in India: a nationally representative survey of adults aged 45 years and older.印度糖尿病的患病率、知晓率、治疗率及控制率：一项针对45岁及以上成年人的全国代表性调查。
Lancet Glob Health. 2025 Sep;13(9):e1543-e1552. doi: 10.1016/S2214-109X(23)00502-8. Epub 2025 Aug 7.
2
Risk of diabetes and expected years in life without diabetes among adults from an urban community in India: findings from a retrospective cohort.印度城市社区成年人的糖尿病风险和无糖尿病预期寿命：一项回顾性队列研究的结果。
BMC Public Health. 2024 Apr 15;24(1):1048. doi: 10.1186/s12889-024-18465-2.
3
Expert Consensus Recommendations on Time in Range for Monitoring Glucose Levels in People with Diabetes: An Indian Perspective.糖尿病患者血糖水平监测的血糖达标时间专家共识建议：印度视角
Diabetes Ther. 2023 Feb;14(2):237-249. doi: 10.1007/s13300-022-01355-4. Epub 2023 Jan 27.
4
In-House Algorithm for Reporting Discrepant HbA1c Result and Troubleshooting a Case of False Low HbA1c.用于报告糖化血红蛋白（HbA1c）结果差异及排查一例糖化血红蛋白假性低值病例的内部算法
EJIFCC. 2021 Oct 18;32(3):377-384. eCollection 2021 Oct.
5
Trends in Laboratory Testing Practice for Diabetes Mellitus.糖尿病实验室检测实践的趋势
EJIFCC. 2020 Sep 29;31(3):231-241. eCollection 2020 Sep.
6
Inverse Association between Iron Deficiency and Glycated Hemoglobin Levels in Ghanaian Adults-the RODAM Study.加纳成年人缺铁与糖化血红蛋白水平呈负相关-RODAM 研究。
J Nutr. 2020 Jul 1;150(7):1899-1908. doi: 10.1093/jn/nxaa109.
7
Isolated HbA1c identifies a different subgroup of individuals with type 2 diabetes compared to fasting or post-challenge glucose in Asian Indians: The CARRS and MASALA studies.与空腹或餐后血糖相比，HbA1c 单独升高可识别出 2 型糖尿病患者中的不同亚组：CARRS 和 MASALA 研究。
Diabetes Res Clin Pract. 2019 Jul;153:93-102. doi: 10.1016/j.diabres.2019.05.026. Epub 2019 May 28.
8
Impact of Anemia and Red Cell Indices on the Diagnosis of Pre-Diabetes and Diabetes in Indian Adult Population: Is there a Cut-off Guide for Clinicians?贫血和红细胞指数对印度成年人群糖尿病前期和糖尿病诊断的影响：是否有临床医生的截断值指南？
Indian J Endocrinol Metab. 2019 Jan-Feb;23(1):91-96. doi: 10.4103/ijem.IJEM_190_18.
9
Glucose patterns during the OGTT and risk of future diabetes in an urban Indian population: The CARRS study.印度城市人群口服葡萄糖耐量试验期间的血糖模式与未来患糖尿病的风险：CARRS研究
Diabetes Res Clin Pract. 2017 Apr;126:192-197. doi: 10.1016/j.diabres.2017.01.009. Epub 2017 Feb 17.
10
Clinical profile, outcomes, and progression to type 2 diabetes among Indian women with gestational diabetes mellitus seen at a diabetes center in south India.在印度南部一家糖尿病中心就诊的患有妊娠期糖尿病的印度女性的临床特征、结局及2型糖尿病进展情况
Indian J Endocrinol Metab. 2014 May;18(3):400-6. doi: 10.4103/2230-8210.131205.
本文引用的文献
1
Prevalence of β-thalassemia and other haemoglobinopathies in six cities in India: a multicentre study.印度六个城市β地中海贫血及其他血红蛋白病的患病率：一项多中心研究
J Community Genet. 2013 Jan;4(1):33-42. doi: 10.1007/s12687-012-0114-0. Epub 2012 Oct 21.
2
Unexpectedly low HbA1c levels in two diabetes patients following dapsone use.两名糖尿病患者使用氨苯砜后糖化血红蛋白（HbA1c）水平意外降低。
Indian J Endocrinol Metab. 2012 Jul;16(4):658-9. doi: 10.4103/2230-8210.98037.
3
Artifactually lowered glycosylated hemoglobin (HbA1c %) in patient with diabetes on dapsone.服用氨苯砜的糖尿病患者糖化血红蛋白（HbA1c%）假性降低
Indian J Endocrinol Metab. 2012 Jul;16(4):657. doi: 10.4103/2230-8210.98036.
4
Drugs affecting HbA1c levels.影响糖化血红蛋白（HbA1c）水平的药物。
Indian J Endocrinol Metab. 2012 Jul;16(4):528-31. doi: 10.4103/2230-8210.98004.
5
Spuriously high prevalence of prediabetes diagnosed by HbA(1c) in young indians partly explained by hematological factors and iron deficiency anemia.HbA(1c) 诊断的年轻印度人前糖尿病患病率偏高，部分原因是血液学因素和缺铁性贫血。
Diabetes Care. 2012 Apr;35(4):797-802. doi: 10.2337/dc11-1321. Epub 2012 Feb 8.
6
Review of hemoglobin A(1c) in the management of diabetes.血红蛋白 A1c 在糖尿病管理中的评价。
J Diabetes. 2009 Mar;1(1):9-17. doi: 10.1111/j.1753-0407.2009.00009.x. Epub 2009 Jan 27.
7
A review of variant hemoglobins interfering with hemoglobin A1c measurement.干扰糖化血红蛋白测量的变异血红蛋白综述。
J Diabetes Sci Technol. 2009 May 1;3(3):446-51. doi: 10.1177/193229680900300307.
8
International Expert Committee report on the role of the A1C assay in the diagnosis of diabetes.国际专家委员会关于糖化血红蛋白检测在糖尿病诊断中作用的报告。
Diabetes Care. 2009 Jul;32(7):1327-34. doi: 10.2337/dc09-9033. Epub 2009 Jun 5.
9
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.磺脲类或胰岛素强化血糖控制与传统治疗及2型糖尿病患者并发症风险的比较（英国前瞻性糖尿病研究[UKPDS 33]）。英国前瞻性糖尿病研究（UKPDS）小组
Lancet. 1998 Sep 12;352(9131):837-53.
10
Global epidemiology of hemoglobin disorders.血红蛋白疾病的全球流行病学。
Ann N Y Acad Sci. 1998 Jun 30;850:251-69. doi: 10.1111/j.1749-6632.1998.tb10482.x.
Zotero 插件