The Key Laboratory of Molecular Medicine, The Ministry of Education, Shanghai Medical School, Fudan University, Shanghai 200433, People's Republic of China.
J Phys Condens Matter. 2013 Sep 18;25(37):374102. doi: 10.1088/0953-8984/25/37/374102. Epub 2013 Aug 15.
The physical properties of a molecular motor with load changing in a wide range will be discussed in this study, in particular the mean velocity, output power and energy efficiency. The main difficulty of this study is that both the states of the molecular motor and the energy barriers between them change with the loading force. Moreover, with the change of load, the number of motor states may also change, so different models should be used to calculate the corresponding physical quantities in different ranges of load. The results show that, in contrast to the usual intuition, the mean velocity and output power of the molecular motor do not change continuously with load.
本研究将讨论在负载大范围变化的情况下,分子马达的物理性质,特别是平均速度、输出功率和能量效率。本研究的主要难点在于分子马达的状态以及它们之间的能量势垒都随加载力而变化。此外,随着负载的变化,马达状态的数量也可能发生变化,因此在不同的负载范围内应使用不同的模型来计算相应的物理量。结果表明,与通常的直觉相反,分子马达的平均速度和输出功率并不随负载连续变化。