Huang Wenyan, Liu Kaishan
Department of Pathology, Medical College, Ji'nan University, Guangzhou 510632, China.
Zhongguo Fei Ai Za Zhi. 2013 Aug 20;16(8):422-6. doi: 10.3779/j.issn.1009-3419.2013.08.06.
The transcription activation of p53 plays an important role in the maintenance of genetic stability. P53 is an intensive study tumor suppressor, which has been called the "gene guider". The p53 family members p63, p73 have high homologous sequence with p53. Some of them can bind to the p53-responsive genes and transcript the downstream genes. Human lung cancer is one of the most common malignant tumors in the world. Abnormality of the p53 gene is the significant event in lung cancers, which leads to the poor prognosis and the resistance of chemotherapy. A deep understanding of the relationship between p53 family members and lung cancers can provide a more reasonably targeted clinical approach. This paper will focus on the special function of p53 family members in the development, chemosensitivity and target treatment of lung cancer.
p53的转录激活在维持遗传稳定性中起重要作用。p53是一个深入研究的肿瘤抑制因子，被称为“基因向导”。p53家族成员p63、p73与p53具有高度同源序列。其中一些成员可与p53反应基因结合并转录下游基因。肺癌是世界上最常见的恶性肿瘤之一。p53基因异常是肺癌中的重要事件，这导致预后不良和化疗耐药。深入了解p53家族成员与肺癌之间的关系可为临床提供更合理的靶向治疗方法。本文将聚焦于p53家族成员在肺癌发生、化疗敏感性及靶向治疗中的特殊作用。
