Department of Clinical Neurophysiology, Seinäjoki Central Hospital, Seinäjoki, Finland.
Physiol Meas. 2013 Sep;34(9):1013-26. doi: 10.1088/0967-3334/34/9/1013. Epub 2013 Aug 14.
Apnea-hypopnea-index (AHI), disregarding the respiratory event morphology, is currently used in estimation of severity of obstructive sleep apnea (OSA). The purpose of the current study was to evaluate the potential of novel parameters in estimation of changes in severity of OSA during weight loss. Polygraphic data of 67 patients, 37 in the control (no weight loss) and 30 in the weight loss (>5%) groups was evaluated at baseline and after two year follow-up. Changes in the values of novel parameters, incorporating detailed information of respiratory event characteristics, were evaluated and compared with changes in AHI. The median AHI in the weight loss group decreased significantly during the follow-up. The number of shorter respiratory events decreased in the weight loss group, while the longer ones remained, increasing the median durations of the respiratory events by 20-62%. For this reason the decrease of the values of the novel parameters were smaller compared to AHI in the weight loss group. This suggests that the severity of OSA might not fall as linearly during weight loss as AHI suggests. Moreover, the novel parameters containing more detailed information on the morphology characteristics may provide valuable supplementary information for the assessment of the severity of OSA.
呼吸暂停-低通气指数（AHI），不考虑呼吸事件形态，目前用于估计阻塞性睡眠呼吸暂停（OSA）的严重程度。本研究的目的是评估新型参数在估计减肥期间 OSA 严重程度变化方面的潜力。对 67 例患者（对照组无减肥 37 例，减肥>5%30 例）的多导睡眠图数据进行了基线和两年随访评估。评估了纳入呼吸事件特征详细信息的新型参数值的变化，并与 AHI 的变化进行了比较。减肥组在随访期间 AHI 显著降低。减肥组较短的呼吸事件数量减少，而较长的呼吸事件仍然存在，使呼吸事件的中位持续时间增加了 20-62%。因此，减肥组新型参数值的降低幅度小于 AHI。这表明，OSA 的严重程度在减肥期间可能不会像 AHI 所提示的那样呈线性下降。此外，包含更多呼吸事件形态特征详细信息的新型参数可能为评估 OSA 的严重程度提供有价值的补充信息。
