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不同盐浓度和温度条件下 DNA 小沟结合的热力学特征。

Different thermodynamic signatures for DNA minor groove binding with changes in salt concentration and temperature.

机构信息

Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.

出版信息

Chem Commun (Camb). 2013 Oct 4;49(76):8543-5. doi: 10.1039/c3cc44569k.

DOI:10.1039/c3cc44569k
PMID:23945614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3791883/
Abstract

The effects of salt concentration and temperature on the thermodynamics of DNA minor groove binding have quite different signatures: binding enthalpy is salt concentration independent but temperature dependent. Conversely, binding free energy is salt dependent but essentially temperature independent through enthalpy-entropy compensation.

摘要

盐浓度和温度对 DNA 小沟结合热力学的影响具有截然不同的特征：结合焓与盐浓度无关，但与温度有关。相反，结合自由能与盐有关，但通过焓熵补偿基本上与温度无关。

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