寻找一种理想的间充质干细胞分离来源，用于再生医学中可能的治疗应用。
Towards an ideal source of mesenchymal stem cell isolation for possible therapeutic application in regenerative medicine.
作者信息
Bellavia Maurizio, Altomare Roberta, Cacciabaudo Francesco, Santoro Alessandra, Allegra Adolfo, Concetta Gioviale Maria, Lo Monte Attilio Ignazio
机构信息
Dipartimento di Discipline Chirurgiche ed Oncologiche (DICHIRON), Universita degli Studi di Palermo, Palermo, Italy.
出版信息
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2014 Sep;158(3):356-60. doi: 10.5507/bp.2013.051. Epub 2013 Jul 29.
BACKGROUND
The possibility of obtaining mesenchymal stem cells (MSCs) from fetal tissue such as amniotic fluid, chorionic villi and placenta is well-known and a comparison between MSCs originating in different sources such as fetal tissue and those from bone marrow in terms of yield and function is a topical issue. The mesenchymal stem cells isolated from bone marrow are well-characterized. Unfortunately the low quantitative yield during isolation is a major problem. For this reason, other tissue sources for MSCs are of paramount importance.
CONCLUSION
In this review, starting from a description of the molecular and cellular biology of MSCs, we describe alternative sources of isolation other than bone marrow. Finally, we describe the potential therapeutic application of these cells.
背景
从羊水、绒毛膜绒毛和胎盘等胎儿组织中获取间充质干细胞（MSCs）的可能性已为人熟知，并且在产量和功能方面，比较源自不同来源（如胎儿组织和骨髓）的间充质干细胞是一个热门话题。从骨髓中分离出的间充质干细胞已得到充分表征。不幸的是，分离过程中产量低是一个主要问题。因此，间充质干细胞的其他组织来源至关重要。
结论
在本综述中，我们从间充质干细胞的分子和细胞生物学描述入手，介绍了除骨髓之外的其他分离来源。最后，我们描述了这些细胞的潜在治疗应用。
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