Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Nanoscale. 2013 Oct 7;5(19):8821-36. doi: 10.1039/c3nr00957b. Epub 2013 Aug 14.
Spinal cord injury results in significant mortality and morbidity, lifestyle changes, and difficult rehabilitation. Treatment of spinal cord injury is challenging because the spinal cord is both complex to treat acutely and difficult to regenerate. Nanomaterials can be used to provide effective treatments; their unique properties can facilitate drug delivery to the injury site, enact as neuroprotective agents, or provide platforms to stimulate regrowth of damaged tissues. We review recent uses of nanomaterials including nanowires, micelles, nanoparticles, liposomes, and carbon-based nanomaterials for neuroprotection in the acute phase. We also review the design and neural regenerative application of electrospun scaffolds, conduits, and self-assembling peptide scaffolds.
脊髓损伤导致高死亡率和发病率、生活方式改变以及康复困难。脊髓损伤的治疗具有挑战性，因为脊髓在急性治疗时既复杂又难以再生。纳米材料可用于提供有效的治疗方法；其独特的性质可以促进药物递送到损伤部位，充当神经保护剂，或提供平台来刺激受损组织的再生。我们回顾了纳米材料（包括纳米线、胶束、纳米颗粒、脂质体和碳基纳米材料）在急性阶段的神经保护作用的最新应用。我们还回顾了静电纺丝支架、导管和自组装肽支架的设计和神经再生应用。
