Schepici Giovanni, Silvestro Serena, Mazzon Emanuela
IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.
Biomedicines. 2023 Jan 13;11(1):201. doi: 10.3390/biomedicines11010201.
Spinal cord injury (SCI) is a devastating condition usually induced by the initial mechanical insult that can lead to permanent motor and sensory deficits. At present, researchers are investigating potential therapeutic strategies to ameliorate the neuro-inflammatory cascade that occurs post-injury. Although the use of mesenchymal stromal/stem (MSCs) as a potential therapy in application to regenerative medicine promoted anti-inflammatory and neuroprotective effects, several disadvantages limit their use. Therefore, recent studies have reported the effects of exosomes-derived MSCs (MSC-EXOs) as an innovative therapeutic option for SCI patients. It is noteworthy that MSC-EXOs can maintain the integrity of the blood-spinal cord barrier (BSCB), promoting angiogenic, proliferative, and anti-oxidant effects, as well as immunomodulatory, anti-inflammatory, and antiapoptotic properties. Therefore, in this study, we summarized the preclinical studies reported in the literature that have shown the effects of MSC-EXOs as a new molecular target to counteract the devastating effects of SCI.
脊髓损伤（SCI）是一种通常由初始机械损伤引起的毁灭性疾病，可导致永久性运动和感觉功能障碍。目前，研究人员正在研究潜在的治疗策略，以改善损伤后发生的神经炎症级联反应。尽管间充质基质/干细胞（MSCs）作为再生医学的一种潜在治疗方法具有抗炎和神经保护作用，但一些缺点限制了它们的应用。因此，最近的研究报道了源自MSCs的外泌体（MSC-EXOs）对SCI患者具有创新治疗作用。值得注意的是，MSC-EXOs可以维持血脊髓屏障（BSCB）的完整性，促进血管生成、增殖和抗氧化作用，以及免疫调节、抗炎和抗凋亡特性。因此，在本研究中，我们总结了文献中报道的临床前研究，这些研究表明MSC-EXOs作为一种新的分子靶点可对抗SCI的毁灭性影响。
