Buffolano W, Filia A, Agnese M, Stronati M, Dicostanzo P
Centro Coordinamento Infezioni Perinatali- Regione Campania, Università Federico II, Napoli, Italia.
Pediatr Med Chir. 2013 May-Jun;35(3):110-7. doi: 10.4081/pmc.2013.43.
Congenital Rubella is the dramatic consequence of rubella during gestation. A combined strategy of Measles and Rubella universal vaccination on children and selective vaccination of susceptible women has been shown effective in the elimination of congenital rubella requiring an incidence of < 1 case of CRS per 100,000 live births. Verification processes of rubella elimination require that physicians early and appropriately diagnose all cases of congenital rubella, including those unpatent at birth. The paper highlights clinical and laboratory aspects channeling diagnosis of congenital rubella infection or syndrome even after the first year of life, and the short- and long-term management criteria.
先天性风疹是孕期感染风疹的严重后果。对儿童进行麻疹和风疹联合普遍接种疫苗以及对易感女性进行选择性接种疫苗的综合策略已被证明在消除先天性风疹方面是有效的,这要求先天性风疹综合征(CRS)发病率低于每10万例活产1例。风疹消除的验证过程要求医生尽早并准确诊断所有先天性风疹病例,包括出生时无症状的病例。本文重点介绍了即使在出生后第一年之后,先天性风疹感染或综合征诊断的临床和实验室方面,以及短期和长期管理标准。