Leclerc Gwladys E, Charleux Fabrice, Ho Ba Tho Marie-Christine, Bensamoun Sabine F
a Laboratoire de BioMécanique et BioIngénierie, Centre de Recherches de Royallieu, Université de Technologie de Compiègne (UTC) , UMR CNRS 7338, Rue Personne de Roberval, BP 20529, 60205 Compiègne Cedex , France.
Comput Methods Biomech Biomed Engin. 2015;18(5):485-91. doi: 10.1080/10255842.2013.818664. Epub 2013 Aug 15.
Magnetic resonance elastography (MRE), based on shear wave propagation generated by a specific driver, is a non-invasive exam performed in clinical practice to improve the liver diagnosis. The purpose was to develop a finite element (FE) identification method for the mechanical characterisation of phantom mimicking soft tissues investigated with MRE technique. Thus, a 3D FE phantom model, composed of the realistic MRE liver boundary conditions, was developed to simulate the shear wave propagation with the software ABAQUS. The assumptions of homogeneity and elasticity were applied to the FE phantom model. Different ranges of mesh size, density and Poisson's ratio were tested in order to develop the most representative FE phantom model. The simulated wave displacement was visualised with a dynamic implicit analysis. Subsequently, an identification process was performed with a cost function and an optimisation loop provided the optimal elastic properties of the phantom. The present identification process was validated on a phantom model, and the perspective will be to apply this method on abdominal tissues for the set-up of new clinical MRE protocols that could be applied for the follow-up of the effects of treatments.
磁共振弹性成像（MRE）基于特定驱动器产生的剪切波传播，是临床实践中用于改善肝脏诊断的一种非侵入性检查。目的是开发一种有限元（FE）识别方法，用于对采用MRE技术研究的模拟软组织体模进行力学表征。因此，开发了一个由逼真的MRE肝脏边界条件组成的三维有限元体模模型，以使用ABAQUS软件模拟剪切波传播。有限元体模模型采用了均匀性和弹性假设。测试了不同范围的网格尺寸、密度和泊松比，以开发最具代表性的有限元体模模型。通过动态隐式分析对模拟的波位移进行可视化。随后，使用成本函数进行识别过程，优化循环提供了体模的最佳弹性特性。目前的识别过程在一个体模模型上得到了验证，未来的前景是将该方法应用于腹部组织，以建立可用于治疗效果随访的新的临床MRE方案。
