Hinting A, Comhaire F, Vermeulen L, Dhont M, Vermeulen A, Vandekerckhove D
Department of Internal Medicine, State University Hospital, Ghent, Belgium.
Hum Reprod. 1990 Jul;5(5):544-8. doi: 10.1093/oxfordjournals.humrep.a137139.
Since relatively few spermatozoa are needed for oocyte fertilization during gamete intra-Fallopian transfer (GIFT) or in-vitro fertilization (IVF), these methods have been applied in couples with infertility due to male causes. Forty-six couples with male factor infertility were enrolled in this study and results were compared with those attained in 48 couples treated with the same techniques for other than male causes. Overall, GIFT resulted in 26% ongoing pregnancies. GIFT seems to be particularly successful when the sperm concentration is 20 x 10(6)/ml or more, but sperm motility and/or morphology are poor. Nine pregnancies occurred out of 26 GIFT cycles in 18 cases selected on this basis. The ongoing pregnancy rate after IVF was 16% per patient. The latter treatment should be attempted in male immune infertility and in cases with a low sperm concentration, with or without abnormal sperm motility and/or morphology. In these circumstances, five pregnancies were attained out of 28 cycles in 14 cases. For similar sperm concentrations, the conception rate per cycle attained with techniques of assisted reproduction was more than twice that attained with conventional treatment of male infertility.
由于在配子输卵管内移植（GIFT）或体外受精（IVF）过程中，卵母细胞受精所需的精子数量相对较少，因此这些方法已应用于因男性因素导致不孕的夫妇。本研究纳入了46对男性因素不孕的夫妇，并将结果与48对因非男性因素采用相同技术治疗的夫妇进行了比较。总体而言，GIFT导致26%的持续妊娠。当精子浓度为20×10⁶/ml或更高，但精子活力和/或形态较差时，GIFT似乎特别成功。在此基础上选择的18例患者的26个GIFT周期中有9例妊娠。IVF后每位患者的持续妊娠率为16%。对于男性免疫性不孕以及精子浓度低、伴有或不伴有精子活力和/或形态异常的情况，应尝试后一种治疗方法。在这些情况下，14例患者的28个周期中有5例妊娠。对于相似的精子浓度，辅助生殖技术每周期的受孕率是男性不育传统治疗方法的两倍多。
