从 NF-κB 的阴影中浮现，SUMOylated IκBα 抑制转录。

Emerging from NF-κB's shadow, SUMOylated IκBα represses transcription.

机构信息

Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne NE2 4HH, UK.

出版信息

Cancer Cell. 2013 Aug 12;24(2):139-40. doi: 10.1016/j.ccr.2013.07.011.

DOI:10.1016/j.ccr.2013.07.011

PMID:23948292

Abstract

In this issue of Cancer Cell, Mulero and colleagues describe an NF-κB independent transcriptional repression function for SUMOylated IκBα. This compelling and provocative model links IκBα to the activity of the Polycomb repressors and provides a mechanism to link inflammatory signaling to skin homeostasis.

摘要

在本期《癌细胞》中，Mulero 及其同事描述了 SUMO 化 IκBα 的 NF-κB 非依赖性转录抑制功能。这一引人注目的挑衅性模型将 IκBα 与 Polycomb 抑制因子的活性联系起来，并提供了一种将炎症信号与皮肤稳态联系起来的机制。