CDK6 在转录中的激酶非依赖性、第二重生命。
The kinase-independent, second life of CDK6 in transcription.
机构信息
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
出版信息
Cancer Cell. 2013 Aug 12;24(2):141-3. doi: 10.1016/j.ccr.2013.07.019.
Abstract
CDK6 is an oncogenic kinase regulating the cell cycle. In this issue of Cancer Cell, Kollmann and colleagues demonstrate that CDK6 performs a kinase-independent transcriptional function in regulating expression of VEGF-A and p16INK4a. These observations link the cell cycle machinery and angiogenesis and reveal the presence of a fail-safe antiproliferative mechanism.
摘要
CDK6 是一种致癌激酶，调节细胞周期。在本期《癌细胞》中，Kollmann 及其同事证明 CDK6 通过激酶非依赖性的转录功能调控 VEGF-A 和 p16INK4a 的表达。这些观察结果将细胞周期机制与血管生成联系起来，并揭示了存在一种故障安全的抗增殖机制。
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