从⁶⁸Ge/⁶⁸Ga发生器洗脱液中定量在线分离⁶⁸Ge，用于突破的纯化和即时质量控制。
Quantitative online isolation of ⁶⁸Ge from ⁶⁸Ge/⁶⁸Ga generator eluates for purification and immediate quality control of breakthrough.
作者信息
Eppard Elisabeth, Loktionova Natalia S, Rösch Frank
机构信息
Institute of Nuclear Chemistry, University of Mainz, D-55128 Mainz, Germany.
出版信息
Appl Radiat Isot. 2013 Dec;82:45-8. doi: 10.1016/j.apradiso.2013.07.020. Epub 2013 Jul 25.
The breakthrough of ⁶⁸Ge from a ⁶⁸Ge/⁶⁸Ga-generator is one of the most sensitive parameters in the context of the clinical application of ⁶⁸Ga-radiopharmaceuticals. The difficulty in its determination lies in the "spectroscopic invisibility" of ⁶⁸Ge within an excess of ⁶⁸Ga. The introduced method for determining the ⁶⁸Ge content of the ⁶⁸Ge/⁶⁸Ga-generator eluate involves the quantitative separation of ⁶⁸Ga from ⁶⁸Ge, using a cation-exchanger. The eluate contains ⁶⁸Ga free of ⁶⁸Ge, which can be determined immediately, i.e. prior to the application of the ⁶⁸Ga-radiopharmaceutical.
⁶⁸Ge从⁶⁸Ge/⁶⁸Ga发生器中的突破是⁶⁸Ga放射性药物临床应用中最敏感的参数之一。其测定的困难在于在过量的⁶⁸Ga中⁶⁸Ge的“光谱不可见性”。所引入的测定⁶⁸Ge/⁶⁸Ga发生器洗脱液中⁶⁸Ge含量的方法涉及使用阳离子交换剂将⁶⁸Ga与⁶⁸Ge定量分离。洗脱液中含有不含⁶⁸Ge的⁶⁸Ga，可立即进行测定，即在应用⁶⁸Ga放射性药物之前进行测定。
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