Jordaan H F, Mulligan R P
Department of Dermatology, Tygerberg Hospital, Private Bag, South Africa.
J Cutan Pathol. 1990 Aug;17(4):236-40. doi: 10.1111/j.1600-0560.1990.tb00092.x.
Exogenous ochronosis is caused by the longterm application of skin-lightening creams containing hydroquinone. This irreversible disfiguring cosmetic problem assumes epidemic proportions in South African blacks. Mild ochronosis is characterized clinically by coarsening and darkening of the skin and severe ochronosis by coalescing, caviar-like black papules and atrophy. Histology shows ochronotic collagen fibres with eventual formation of ochronotic colloid milium. A variable cellular infiltrate, which may be granulomatous, is present. We describe a 39-year-old black woman with severe exogenous ochronosis who developed superimposed annular lesions with granulomatous histology bearing great resemblance to lesions of actinic granuloma.
外源性褐黄病是由长期使用含对苯二酚的美白面霜引起的。这种不可逆转的毁容性美容问题在南非黑人中呈流行趋势。轻度褐黄病的临床特征是皮肤粗糙和变黑，重度褐黄病则表现为融合性、鱼子样黑色丘疹和萎缩。组织学显示褐黄病性胶原纤维，最终形成褐黄病性胶样粟丘疹。存在可变的细胞浸润，可能为肉芽肿性。我们描述了一名39岁患有严重外源性褐黄病的黑人女性，其出现了叠加的环形皮损，组织学表现为肉芽肿性，与光化性肉芽肿的皮损极为相似。
