肺微粒体的电子传递系统及其生理功能。苯胺和类固醇的酶促羟化作用。
Electron transport systems of lung microsomes and their physiological functions. Enzymic hydroxylation of aniline and steroids.
作者信息
Matsubara T, Nakamura Y, Tochino Y
出版信息
Xenobiotica. 1975 Apr;5(4):205-12. doi: 10.3109/00498257509052067.
PMID:239487
Abstract
- The hydroxylation of aniline by rabbit lung microsomes to rho-aminophenol required oxygen and NADPH, and was inhibited by menadione, ferricytochrome c and carbon monoxide. 2. NADH was a less effective electron donor than NADPH in this reaction, but its addition significantly increased the yield of rho-aminophenol formed in the presence of NADPH. 3. 4,16-Androstadien-3-one and 3beta-hydroxy-5-androsten-17-one were also metabolized by lung microsomes to the same products as are formed by hepatic microsomes.
摘要
- 兔肺微粒体将苯胺羟基化为对氨基苯酚需要氧气和NADPH，并受到甲萘醌、高铁细胞色素c和一氧化碳的抑制。2. 在该反应中，NADH作为电子供体的效果不如NADPH，但添加NADH能显著提高在NADPH存在时形成的对氨基苯酚的产量。3. 4,16-雄甾二烯-3-酮和3β-羟基-5-雄甾烯-17-酮也被肺微粒体代谢为与肝微粒体形成的相同产物。
Zotero 插件