羟丙基甲基纤维素在玻璃体中的药代动力学的分子量依赖性

Molecular weight dependence of the pharmacokinetic of hydroxypropyl methylcellulose in the vitreous.

作者信息

Fernandez-Vigo J, Sabugal J F, Diaz Rey A, Concheiro A, Martinez R

机构信息

Department of Ophthalmology, School of Medicine, University of Santiago de Compostela, Spain.

出版信息

J Ocul Pharmacol. 1990 Summer;6(2):137-42. doi: 10.1089/jop.1990.6.137.

DOI:10.1089/jop.1990.6.137

PMID:2394933

Abstract

The influence of molecular weight on the elimination kinetics of the potential vitreous substitute hydroxypropyl methylcellulose (HPMC) was studied using solutions of equal viscosity (15,000 cps) of HPMC of molecular weight 86,000 daltons (HPMC 86,000) and HPMC of molecular weight 120,000 daltons (HPMC 120,000). Three days after gas vitrectomy of the right eyes of 64 rabbits, the gas was replaced by 0.5 ml of HPMC solution (2.5% HPMC 86,000 in 39 and 2% HPMC 120,000 solution in 25); HPMC concentration was determined immediately afterwards and 7, 14, 30, 60 and 90 days later by the diphenylamine method, the left eyes being used as blanks. HPMC elimination exhibited order one kinetics, with a half life of 10.4 days for HPMC 86,000 and 38.4 days for HPMC 120,000. These results suggest that by choosing HPMC of suitable molecular weight it may be possible to control the residence time of the polymer in the vitreous cavity.

摘要

使用分子量为86,000道尔顿的羟丙基甲基纤维素（HPMC 86,000）和分子量为120,000道尔顿的羟丙基甲基纤维素（HPMC 120,000）的等粘度溶液（15,000厘泊），研究了分子量对潜在玻璃体替代物羟丙基甲基纤维素（HPMC）消除动力学的影响。对64只兔子的右眼进行气体玻璃体切除术后三天，用0.5毫升HPMC溶液（39只眼中为2.5%的HPMC 86,000，25只眼中为2%的HPMC 120,000溶液）替代气体；随后立即以及7、14、30、60和90天后通过二苯胺法测定HPMC浓度，左眼用作空白对照。HPMC的消除呈现一级动力学，HPMC 86,000的半衰期为10.4天，HPMC 120,000的半衰期为38.4天。这些结果表明，通过选择合适分子量的HPMC，有可能控制聚合物在玻璃体腔中的停留时间。