Vogel R, Clineschmidt C M, Hoeh H, Kulaga S F, Tipping R W
Department of Clinical Research, Merck Sharp & Dohme Research Laboratories, West Point, PA.
J Ocul Pharmacol. 1990 Summer;6(2):85-90. doi: 10.1089/jop.1990.6.85.
This study in sixty healthy volunteers investigated the effect of a single drop of either 0.5% timolol ophthalmic solution, 0.5% betaxolol ophthalmic solution, or placebo on corneal sensitivity as measured by the Cochet-Bonnet anesthesiometer. Corneal sensitivity was measured immediately prior to the drop and then 1, 3, 6, 10, 15 and 30 minutes after drop instillation. The timolol treated eyes showed a significant decrease at one minute after instillation. An increase in sensitivity occurred in the placebo group at 15 and 30 minutes. In the eyes treated with betaxolol, a significant reduction in corneal sensitivity was seen at every time point through the 10-minute measurement.
这项针对60名健康志愿者的研究，调查了一滴0.5%噻吗洛尔眼药水、0.5%倍他洛尔眼药水或安慰剂对角膜敏感性的影响，角膜敏感性通过科谢-博内麻醉计进行测量。在滴眼剂滴入前即刻以及滴入后1、3、6、10、15和30分钟测量角膜敏感性。滴入噻吗洛尔的眼睛在滴入后1分钟显示出显著下降。安慰剂组在15和30分钟时敏感性增加。在用倍他洛尔治疗的眼睛中，在10分钟测量的每个时间点都观察到角膜敏感性显著降低。
