Translational Cardiomyology Lab, Department of Development and Regeneration, Stem Cell Institute Leuven, Embryo and Stem Cell Biology, KU Leuven, Herestraat 49, O&N4, Bus 814, 3000, Leuven, Belgium.
Cell Mol Life Sci. 2014 Feb;71(4):615-27. doi: 10.1007/s00018-013-1445-7. Epub 2013 Aug 15.
Regenerative medicine for skeletal and cardiac muscles still constitutes a fascinating and ambitious frontier. In this perspective, understanding the possibilities of intrinsic cell plasticity, present in post-natal muscles, is vital to define and improve novel therapeutic strategies for acute and chronic diseases. In addition, many somatic stem cells are now crossing the boundaries of basic/translational research to enter the first clinical trials. However, it is still an open question whether a lineage switch between skeletal and cardiac adult myogenesis is possible. Therefore, this review focuses on resident somatic stem cells of post-natal skeletal and cardiac muscles and their plastic potential toward the two lineages. Furthermore, examples of myogenic lineage switch in adult stem cells are also reported and discussed.
再生医学在骨骼和心肌领域仍然是一个令人着迷且雄心勃勃的前沿领域。从这一角度来看，了解出生后肌肉中内在细胞可塑性的可能性对于定义和改进急性和慢性疾病的新治疗策略至关重要。此外，许多体干细胞现在正在跨越基础/转化研究的界限，进入首次临床试验。然而，在骨骼和心脏成体肌发生之间是否可能发生谱系转换仍然是一个悬而未决的问题。因此，本综述重点关注出生后骨骼和心肌的驻留体干细胞及其向两个谱系的可塑性潜力。此外，还报告和讨论了成年干细胞中肌生成谱系转换的例子。
