García-Fernández Lisset, Hernández Adrián V, Suárez Moreno Víctor, Fiestas Fabián
Unidad de Análisis y Generación de Evidencias en Salud Pública, Instituto Nacional de Salud, Lima, Perú
Rev Peru Med Exp Salud Publica. 2013 Apr;30(2):268-74.
Vaccination is one of the most important public health interventions in the reduction childhood morbidity and mortality. Thimerosal is an organic mercury compound used as preservante in multi-dose vials. Often in Peru, there are waves of controversy about the safety of this type of vaccines, mainly arguing that there is an association between them and autism. As a result of these controversies, there have been some voices asking for laws banning thimerosal-containing vaccines, which would have a large impact in costs and the logistic aspects of the public vaccination programs. The aim of this article is to review the literature for the main controversies about thimerosal in vaccines and its supposed association to autism. We made an historical review about these controversies given the available scientific evidence and the statements from important international organizations. We concluded that the current available evidence do not support an association between thimerosal and childhood neurodevelopmental disorders, such as autism.
疫苗接种是降低儿童发病率和死亡率最重要的公共卫生干预措施之一。硫柳汞是一种有机汞化合物,用作多剂量瓶中的防腐剂。在秘鲁,这类疫苗的安全性常常引发争议浪潮,主要论点是它们与自闭症之间存在关联。由于这些争议,出现了一些要求制定法律禁止含硫柳汞疫苗的呼声,这将对公共疫苗接种计划的成本和后勤方面产生重大影响。本文旨在回顾关于疫苗中硫柳汞及其与自闭症假定关联的主要争议的文献。鉴于现有科学证据和重要国际组织的声明,我们对这些争议进行了历史回顾。我们得出的结论是,目前可得的证据不支持硫柳汞与儿童神经发育障碍(如自闭症)之间存在关联。