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[接受高效抗逆转录病毒治疗的艾滋病毒/艾滋病患者中由贝氏等孢球虫引起的复发性腹泻]

[Recurrent diarrhea due to Cystoisopora belli in HIV/AIDS patients receiving HAART].

作者信息

Montalvo Raúl, Ticona Eduardo, Ñavincopa Marcos, García Yuri, Chávez Gonzalo, Chávez Víctor, Arévalo Jorge, Soria Jaime, Huiza Alina

机构信息

Servicio de Enfermedades Infecciosas y Tropicales, Hospital Daniel Alcides Carrión, Huancayo, Perú

出版信息

Rev Peru Med Exp Salud Publica. 2013 Apr;30(2):326-30.

Abstract

The Cystoisospora belli, before denominated as Isospora belli, is the etiologic agent of cystoisosoporiasis, an opportunistic infection affecting immunocompromised patients, characterized by chronic diarrhea and weight loss. The incidence of chronic diarrhea for this agent, in HIV patients, has decreased considerably. This thanks to the advent of highly active antiretroviral therapy (HAART), which has improved the patient's immune response and decrease viral load. We present six cases of cystoisosoporiasis recurrent and refractory to treatment in HIV patients, who was being treated with with trimethoprim / sulfamethoxazole (TMP / SMX) orally as a prophylaxis. Five of these patients passed away due to the infection, despite of the fact that they had a good response to HAART (adequate increase in CD4 and viral load undetectable) and they had been treated with second line drugs.

摘要

贝氏等孢球虫(以前称为贝氏等孢子球虫)是等孢球虫病的病原体,是一种影响免疫功能低下患者的机会性感染,其特征为慢性腹泻和体重减轻。在HIV患者中,由该病原体引起的慢性腹泻发病率已大幅下降。这得益于高效抗逆转录病毒疗法(HAART)的出现,该疗法改善了患者的免疫反应并降低了病毒载量。我们报告了6例HIV患者反复发生且治疗难治的等孢球虫病病例,这些患者正在口服甲氧苄啶/磺胺甲恶唑(TMP/SMX)进行预防治疗。尽管其中5名患者对HAART反应良好(CD4充分增加且病毒载量检测不到)并接受了二线药物治疗,但仍因感染死亡。

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