Rho 激酶：调节、（功能）异常和抑制。
Rho-kinase: regulation, (dys)function, and inhibition.
出版信息
Biol Chem. 2013 Nov;394(11):1399-410. doi: 10.1515/hsz-2013-0181.
Abstract
In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and adhesion plaques as well as in the regulation of transcription factors. Thus, ROCKI/II activity regulates cellular contraction, motility, morphology, polarity, cell division, and gene expression. Emerging evidence suggests that dysregulation of the Rho-ROCK pathways at different stages is linked to cardiovascular, metabolic, and neurodegenerative diseases as well as cancer. This review focuses on the current status of understanding the multiple functions of Rho-ROCK signaling pathways and various modes of regulation of Rho-ROCK activity, thereby orchestrating a concerted functional response.
摘要
在多种正常和病理细胞类型中，Rho 激酶 I 和 II（ROCKI/II）在非肌肉和平滑肌细胞骨架和黏附斑的组织以及转录因子的调节中发挥关键作用。因此，ROCKI/II 的活性调节细胞收缩、运动、形态、极性、细胞分裂和基因表达。新出现的证据表明，Rho-ROCK 途径在不同阶段的失调与心血管、代谢和神经退行性疾病以及癌症有关。这篇综述重点介绍了目前对 Rho-ROCK 信号通路的多种功能以及 Rho-ROCK 活性的各种调节方式的理解，从而协调了协调一致的功能反应。
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