Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmacol Rep. 2013;65(3):593-9. doi: 10.1016/s1734-1140(13)71036-3.
Long-term exposure to opiates induces physical dependence; however, the neurobiological mechanisms of this phenomenon are not completely clear. The purpose of this study was to evaluate the effects of systemic and intracerebroventricular (icv) administration of selegiline (a selective inhibitor of monoamine oxidase B) on the morphine withdrawal syndrome in rats.
To this aim, adult male Sprague Dawley rats were selected randomly, and then growing doses of morphine were administered subcutaneously at an interval of 12 h for nine days with the intention of inducing dependency. Nine days after, only the morning dose of morphine was administered, followed by systemic or central injection of saline or selegiline. Later, naloxone was injected after 30 min and withdrawal signs recorded for a period of 60 min.
Results showed failure of systemic administration of selegiline in changing the withdrawal symptoms; nevertheless, icv injection attenuated the withdrawal signs significantly.
In conclusion we found that central administration of selegiline attenuated morphine withdrawal symptoms.
长期接触阿片类药物会导致身体依赖；然而，这种现象的神经生物学机制尚不完全清楚。本研究的目的是评估系统和脑室内（icv）给予司来吉兰（一种单胺氧化酶 B 的选择性抑制剂）对大鼠吗啡戒断综合征的影响。
为此，选择成年雄性 Sprague Dawley 大鼠进行随机分组，然后每隔 12 小时皮下给予递增剂量的吗啡，共九天，以诱导依赖。九天后，仅给予早晨剂量的吗啡，随后进行生理盐水或司来吉兰的全身或中枢注射。30 分钟后注射纳洛酮，并记录 60 分钟的戒断症状。
结果表明，全身给予司来吉兰并不能改变戒断症状；然而，脑室内注射显著减轻了戒断症状。
总之，我们发现脑室内给予司来吉兰可减轻吗啡戒断症状。
