Department of Medical and Surgery Specialties, Psychiatry Unit, University Hospital Policlinico-Vittorio Emanuele, Catania, Sicily, Italy.
Neuropsychiatr Dis Treat. 2013;9:1095-9. doi: 10.2147/NDT.S47293. Epub 2013 Aug 6.
Capgras syndrome consists of the delusional belief that a person or persons have been replaced by doubles or impostors. It can occur in the context of both psychiatric and organic illness, and seems to be related to lesions of the bifrontal and right limbic and temporal regions. Indeed, magnetic resonance imaging has revealed brain lesions in patients suffering from Capgras syndrome. This case study reports the findings of a thorough diagnostic evaluation in a woman suffering from Capgras syndrome and presenting with the following clinical peculiarities: obsessive modality of presentation of the delusional ideation, intrusiveness of such ideation (that even disturbed her sleep), as well as a sense of alienation and utter disgust towards the double. These characteristics bring to mind the typical aspects of obsessive-compulsive disorder. Neuroanatomic investigation, through magnetic resonance imaging, performed on this patient showed alteration of the bilateral semioval centers, which are brain regions associated with the emotion of disgust and often show alterations in subjects suffering from obsessive-compulsive disorder. Hence, neuroimaging allows researchers to put forward the hypothesis of a common neuroanatomic basis for Capgras syndrome and obsessive-compulsive disorder, at least for cases in which the delusional ideation is associated with deep feelings of disgust and presents with a certain pervasiveness.
卡普格拉综合征的特点是妄想他人被替身或冒名顶替者所取代。它可能出现在精神疾病和器质性疾病的背景下，似乎与额极和右侧边缘和颞叶区域的损伤有关。事实上，磁共振成像已经揭示了患有卡普格拉综合征的患者存在脑部损伤。本病例研究报告了一位患有卡普格拉综合征并表现出以下临床特征的女性的全面诊断评估结果：妄想观念呈现出强迫模式，这种观念具有侵入性（甚至干扰了她的睡眠），以及对替身的疏远和极度厌恶感。这些特征让人联想到强迫症的典型方面。对该患者进行的磁共振成像神经解剖学研究显示双侧半卵圆中心的改变，这些区域与厌恶情绪有关，并且经常在强迫症患者中出现改变。因此，神经影像学使研究人员能够提出卡普格拉综合征和强迫症具有共同神经解剖基础的假说，至少对于那些与深深的厌恶感相关并具有一定普遍性的妄想观念的病例是如此。
