Domínguez S, Piezzi R S, Scardapane L, Guzmán J A
Cátedras de Histología y Farmacología, Universidad Nacional de San Luis, Mendoza, Argentina.
J Pineal Res. 1990;8(4):367-74. doi: 10.1111/j.1600-079x.1990.tb00897.x.
Lanthanum hydroxide together with a fixative solution was injected into the third ventricle of the viscacha. The tracer penetrated freely into the pineal gland demonstrating an extensive network of intercommunicating intercellular spaces. Numerous gap junctions were observed indicating that they are the predominant interparenchymal contacts. The capillaries were characterized by non-fenestrated endothelial cells lining a moderate-sized perivascular space. Precipitates of lanthanum hydroxide were found in the basal membranes of the perivascular and interendothelial spaces, but not in the vascular lumina. The tracer stopped at tight junctions; these constitute a barrier between the pinealocytes and the blood compartment. Active micropinocytosis observed in the capillary walls suggest a transendothelial transport.
将氢氧化镧与固定液一起注入绒鼠的第三脑室。示踪剂自由穿透进入松果体，显示出广泛的相互连通的细胞间隙网络。观察到大量缝隙连接，表明它们是实质细胞间的主要连接方式。毛细血管的特征是由非窗孔状内皮细胞衬里，周围有适度大小的血管周隙。在血管周隙和内皮细胞间的基底膜中发现了氢氧化镧沉淀，但血管腔内未发现。示踪剂在紧密连接处停止；这些紧密连接构成了松果体细胞与血液腔之间的屏障。在毛细血管壁中观察到的活跃微胞饮作用提示存在跨内皮运输。
