Kalouda Pelagia, Anastasakis Anastasios, Tsika Chrysanthi, Tsilimbaris K Miltiadis
University of Crete Medical School, Department of Ophthalmology , Heraklion , Greece.
Semin Ophthalmol. 2015 Jan;30(1):6-10. doi: 10.3109/08820538.2013.807852. Epub 2013 Aug 16.
To evaluate the effect of anti-VEGF treatment on pigment epithelial detachment (PED) secondary to the exudative type of age-related macular degeneration (AMD).
Retrospective analysis of 30 eyes (28 patients) with exudative AMD accompanied by PED (receiving anti-VEGF injections). Alterations of the PED morphology were qualitatively assessed with optical coherence tomography (OCT). Changes in best-corrected visual acuity (BCVA) and number of injections were compared to 30 control eyes (30 patients) exhibiting exudative AMD without PED.
Mean follow-up was 19.8 months. Changes of the extent of PED were as follows: unchanged: 11 eyes (36.7%); reduced: 12 (40%); significantly reduced: 7 (23.3%). Mean paired difference in BCVA was -0.08 logMAR (p = 0.46) and in the number of injections was 2.1 injections (p = 0.04).
A substantial number of the studied patients showed reduction of the extent of the PED after anti-VEGF treatment. The PED group required a higher number of injections.
评估抗血管内皮生长因子（VEGF）治疗对渗出型年龄相关性黄斑变性（AMD）继发色素上皮脱离（PED）的疗效。
回顾性分析30例（28眼）伴有PED的渗出型AMD患者（接受抗VEGF注射治疗）。采用光学相干断层扫描（OCT）对PED形态改变进行定性评估。将最佳矫正视力（BCVA）变化及注射次数与30例（30眼）无PED的渗出型AMD对照眼进行比较。
平均随访19.8个月。PED范围变化如下：无变化：11眼（36.7%）；缩小：12眼（40%）；显著缩小：7眼（23.3%）。BCVA平均配对差值为-0.08 logMAR（p = 0.46），注射次数平均配对差值为2.1次（p = 0.04）。
大量研究患者在抗VEGF治疗后PED范围缩小。PED组需要更多的注射次数。
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