渗出性年龄相关性黄斑变性中内皮素-1与一氧化氮水平
Endothelin-1 and Nitric Oxide Levels in Exudative Age-Related Macular Degeneration.
作者信息
Totan Yϋksel, Koca Cemile, Erdurmuş Mesut, Keskin Uğurcan, Yiğitoğlu Ramazan
机构信息
Department of Ophthalmology, Turgut Özal University Medical School, Ankara, Turkey.
Department of Biochemistry, Yıldırım Beyazıt University Medical School, Ankara, Turkey.
出版信息
J Ophthalmic Vis Res. 2015 Apr-Jun;10(2):151-4. doi: 10.4103/2008-322X.163765.
PURPOSE
To evaluate plasma levels of endothelin-1 (ET-1) and nitric oxide (NO) in patients with exudative age-related macular degeneration (AMD).
METHODS
In this study, ET-1 levels, as well as nitrite plus nitrate concentrations as an indicator of plasma NO level, were measured in the plasma of 20 subjects with exudative AMD and compared with 20 healthy age and sex matched controls.
RESULTS
Mean plasma ET-1 level was significantly higher in exudative AMD patients as compared to control subjects (0.35 ± 0.06 fmol/ml versus 0.17 ± 0.03 fmol/ml, P = 0.015). Patients with exudative AMD also showed significantly lower mean plasma levels of nitrite plus nitrate as compared to the controls (58.9 ± 2.7 µmol/l versus 82.6 ± 5.9 µmol/l, P = 0.001).
CONCLUSION
Increased concentrations of ET-1 and reduced levels of NO in the plasma may suggest an imbalance between vasoconstrictor and vasodilator agents, respectively, as a reflection of endothelial dysfunction in the pathogenesis of AMD. These findings may also imply the role of vasoconstriction in exudative AMD.
目的
评估渗出性年龄相关性黄斑变性（AMD）患者血浆中内皮素-1（ET-1）和一氧化氮（NO）的水平。
方法
在本研究中，测量了20例渗出性AMD患者血浆中的ET-1水平以及作为血浆NO水平指标的亚硝酸盐加硝酸盐浓度，并与20名年龄和性别匹配的健康对照者进行比较。
结果
与对照受试者相比，渗出性AMD患者的平均血浆ET-1水平显著更高（0.35±0.06 fmol/ml对0.17±0.03 fmol/ml，P = 0.015）。与对照组相比，渗出性AMD患者的亚硝酸盐加硝酸盐平均血浆水平也显著更低（58.9±2.7 μmol/l对82.6±5.9 μmol/l，P = 0.001）。
结论
血浆中ET-1浓度升高和NO水平降低可能分别提示血管收缩剂和血管舒张剂之间的失衡，这反映了AMD发病机制中的内皮功能障碍。这些发现也可能暗示血管收缩在渗出性AMD中的作用。
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