[患有缺血性心脏病的中青年男性动脉的结构和功能状态]

[Structural and functional status of arteries in young and middle-aged men with ischemic heart disease].

作者信息

Kozlov S G, Balakhonova T V, Makhmudova Kh A, Tripoten' M I, Andrievskaia M V, Rogoza A N

出版信息

Kardiologiia. 2013;53(5):13-9.

Abstract

Aim of the study was to determine whether structural and functional status of arteries differ between young and middle-aged men with ischemic heart disease (IHD). A total of 78 men aged 28 to 50 years were recruited in this study: 49 with angiographically proven obstructive atherosclerosis of coronary arteries, 29 without clinical manifestations of IHD (control group). Those with arterial hypertension, diabetes mellitus or marked hypercholesterolemia (LDL cholesterol more or equal 4.5 mmol/l) were excluded from the study. All patients underwent carotid ultrasound, endothelial function, and arterial stiffness measurements. Patients with IHD more often had multiple carotid plaques (86.7% vs 13.7%, p<0.001), and increased aortic pulse wave velocity (PWV) assessed by ultrasound duplex scanning (53.1% vs. 24.1%, p=0.02). Aortic PWV was related to the severity of coronary atherosclerosis. Presence of a carotid intima-media thickness more or equal 0.9 mm and abnormal flow-mediated dilatation (FMD) of the brachial artery was not significantly different between the groups.

摘要

本研究的目的是确定患有缺血性心脏病（IHD）的年轻男性和中年男性之间动脉的结构和功能状态是否存在差异。本研究共招募了78名年龄在28至50岁之间的男性：49名经血管造影证实患有冠状动脉阻塞性动脉粥样硬化，29名无IHD临床表现（对照组）。患有动脉高血压、糖尿病或显著高胆固醇血症（低密度脂蛋白胆固醇≥4.5 mmol/l）的患者被排除在研究之外。所有患者均接受了颈动脉超声、内皮功能和动脉僵硬度测量。IHD患者更常出现多发颈动脉斑块（86.7%对13.7%，p<0.001），并且经超声双功扫描评估的主动脉脉搏波速度（PWV）增加（53.1%对24.1%，p=0.02）。主动脉PWV与冠状动脉粥样硬化的严重程度相关。两组之间颈动脉内膜中层厚度≥0.9 mm和肱动脉血流介导的扩张（FMD）异常的情况无显著差异。