Hadjilaskari P, Roehrig G, Hartmann R, Fengler R, Henze G
Universitätskinderklinik Berlin, Abt. Hämatologie/Onkologie.
Klin Padiatr. 1990 Jul-Aug;202(4):275-7. doi: 10.1055/s-2007-1025533.
This retrospective analysis evaluates the effect of intravenously administered immunoglobulin against infections occurring during bone marrow depression after cancer chemotherapy in 85 children with leukemia and lymphoma. There was no statistical difference between patients with and without immunoglobulin administration neither when immunoglobulins were used prophylactically nor therapeutically in addition to antibodies during episodes of infection. Duration of fever, duration of antibiotic therapy, maximum of temperature, white blood cell counts, and kind of infections were comparable in 84 fever episodes in patients who had received immunoglobulin therapeutically and 69 fever episodes in patients who had not. This study supports the aspect that immunoglobulin administration does not have preventive or therapeutic efficacy on infections during cancer chemotherapy in children.
这项回顾性分析评估了静脉注射免疫球蛋白对85名白血病和淋巴瘤患儿癌症化疗后骨髓抑制期间发生感染的影响。在感染发作期间，无论是预防性使用免疫球蛋白还是在使用抗体的基础上进行治疗性使用，接受免疫球蛋白治疗的患者和未接受免疫球蛋白治疗的患者之间均无统计学差异。接受免疫球蛋白治疗的患者的84次发热发作和未接受免疫球蛋白治疗的患者的69次发热发作在发热持续时间、抗生素治疗持续时间、最高体温、白细胞计数以及感染类型方面具有可比性。本研究支持免疫球蛋白给药对儿童癌症化疗期间的感染没有预防或治疗效果这一观点。
