Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Surgery, Ersta Hospital, Stockholm, Sweden.
Eur J Surg Oncol. 2013 Oct;39(10):1079-86. doi: 10.1016/j.ejso.2013.07.091. Epub 2013 Aug 15.
Even though sexual dysfunction has been reported after rectal cancer treatment, information on preoperative sexual function is scarce, particularly in female patients.
To describe preoperative sexual function in women with rectal cancer, and to analyse potential sources of bias.
The Female Sexual Function Index (FSFI) was administered to women with newly diagnosed non-metastatic rectal cancer, irrespective of whether they were sexually active or not. FSFI total and domain scores were calculated for women with complete responses to the corresponding items. Data were compared for those who did and did not complete all the FSFI domains, and for women in the study cohort, and those who were eligible for inclusion but not included.
Sexual inactivity was common. Mean FSFI total score was low (16.4 ± 10.6 SD) among the women who completed all six FSFI domains. The proportion of women who had a partner was higher in this group compared with those who did not complete all the domains (49 of 57 vs 7 of 25, p < 0.001). Eighty-two of the 157 women eligible for inclusion were included. Included women were younger (p = 0.002) and had less co-morbidity than those who were not included (p = 0.025).
The low FSFI total score indicates sexual dysfunction. However, the use of FSFI in both women who are and who are not sexually active complicates interpretation of the data and may result in an information bias hampering internal validity. External validity may be limited by selection bias.
尽管直肠癌治疗后会出现性功能障碍，但术前性功能的信息却很少，尤其是在女性患者中。
描述直肠癌女性患者的术前性功能，并分析潜在的偏倚来源。
对新诊断为非转移性直肠癌的女性患者进行女性性功能指数（FSFI）问卷调查，无论其是否有性行为。对完整回答相应项目的女性计算 FSFI 总分和各领域得分。比较了完成所有 FSFI 领域和未完成所有 FSFI 领域的女性，以及研究队列中的女性和符合纳入标准但未纳入的女性。
性行为不活跃很常见。在完成所有六个 FSFI 领域的女性中，平均 FSFI 总分较低（16.4±10.6 SD）。在这组女性中，有伴侣的比例高于未完成所有领域的女性（49/57 比 7/25，p<0.001）。157 名符合纳入标准的女性中，有 82 名被纳入。纳入的女性比未纳入的女性更年轻（p=0.002），合并症更少（p=0.025）。
FSFI 总分较低表明存在性功能障碍。然而，FSFI 既用于有性行为的女性，也用于无性行为的女性，这使得数据的解释变得复杂，并可能导致信息偏倚，从而影响内部有效性。外部有效性可能受到选择偏倚的限制。
