一种基于 squaraine 和 Hg(2+)的用于半胱氨酸的比色和“开启”荧光探针。
A squaraine and Hg(2+)-based colorimetric and "turn on" fluorescent probe for cysteine.
机构信息
Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education, and Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, PR China.
出版信息
Talanta. 2013 Sep 30;114:66-72. doi: 10.1016/j.talanta.2013.04.006. Epub 2013 Apr 12.
A novel squaraine derivative (SQ-1) was synthesized and characterized for the determination of cysteine. Binding with Hg(2+) as a fluorescent quencher to SQ-1 leads to absorption and emission turn-off. More significantly, the SQ-1-Hg(2+) complex exhibits a dual-channel chromofluorogenic responses to biologically important cysteine with a high sensitivity and selectivity over other natural amino acids, along with a low detection limit of 36.7 nM.
一种新型方酸衍生物（SQ-1）被合成并进行了表征，用于半胱氨酸的测定。与 Hg(2+)结合作为荧光猝灭剂导致 SQ-1 的吸收和发射关闭。更重要的是，SQ-1-Hg(2+)配合物对生物重要的半胱氨酸表现出双通道比色荧光响应，具有高灵敏度和选择性，优于其他天然氨基酸，检测限低至 36.7 nM。
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