Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool, L69 3GJ, UK.
J Am Soc Mass Spectrom. 2013 Oct;24(10):1493-500. doi: 10.1007/s13361-013-0704-z. Epub 2013 Aug 18.
The predicted performance of a quadrupole mass filter (QMF) operating in Mathieu stability zone 3 is described in detail using computer simulations. The investigation considers the factors that limit the ultimate maximum resolution (Rmax) and percentage transmission (%Tx), which can be obtained for a given QMF for a particular scan line of operation. The performance curve (i.e., the resolution (R) versus number (N) of radio frequency (rf) cycles experienced by the ions in the mass filter) has been modeled for the upper and lower tip of stability zone 3. The saturation behavior of the performance curve observed in practice for zone 3 is explained. Furthermore, new design equations are presented by examining the intersection of the scan line with stability zone 3. Resolution versus transmission characteristics of stability zones 1 and 3 are compared and the dependence of performance for zones 1 and 3 is related to particular instrument operating parameters.
使用计算机模拟详细描述了工作在马蒂厄稳定区 3 的四极滤质器 (QMF) 的预测性能。该研究考虑了限制最大分辨率 (Rmax) 和传输百分比 (%Tx) 的因素，这两个参数是为给定的 QMF 在特定的扫描线操作中获得的。为稳定性区 3 的上限和下限，对性能曲线（即分辨率 (R) 与质量滤波器中离子经历的射频 (rf) 周期数 (N) 之间的关系）进行了建模。解释了在实际操作中观察到的区 3 中性能曲线的饱和行为。此外，通过检查扫描线与稳定性区 3 的交点，提出了新的设计方程。比较了稳定性区 1 和 3 的分辨率与传输特性，并将区 1 和 3 的性能依赖性与特定的仪器操作参数相关联。
