Department of Pediatric Oncology, Hematology and Immunology, University of Heidelberg, Heidelberg, Germany,
J Mol Med (Berl). 2013 Nov;91(11):1257-71. doi: 10.1007/s00109-013-1074-5. Epub 2013 Aug 17.
Thrombin is the protease involved in blood coagulation. Its deregulation can lead to hemostatic abnormalities, which range from subtle subclinical to serious life-threatening coagulopathies, i.e., during septicemia. Additionally, thrombin plays important roles in many (patho)physiological conditions that reach far beyond its well-established role in stemming blood loss and thrombosis, including embryonic development and angiogenesis but also extending to inflammatory processes, complement activation, and even tumor biology. In this review, we will address thrombin's broad roles in diverse (patho)physiological processes in an integrative way. We will also discuss thrombin as an emerging major target for novel therapies.
凝血酶是参与血液凝固的蛋白酶。其失调可导致止血异常，范围从微妙的亚临床到严重的危及生命的凝血疾病，即在败血症期间。此外，凝血酶在许多（病理）生理条件下发挥重要作用，这些作用远远超出了其在止血和血栓形成方面的既定作用，包括胚胎发育和血管生成，但也延伸到炎症过程、补体激活，甚至肿瘤生物学。在这篇综述中，我们将以综合的方式讨论凝血酶在各种（病理）生理过程中的广泛作用。我们还将讨论凝血酶作为一种新兴的主要治疗靶点的新疗法。
