Rosai-Dorfman 病与 IgG4 相关疾病的关系：32 例研究。

Relationship between Rosai-Dorfman disease and IgG4-related disease: study of 32 cases.

机构信息

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA.

出版信息

Am J Clin Pathol. 2013 Sep;140(3):395-402. doi: 10.1309/AJCPFH0SJ6YILXJU.

DOI:10.1309/AJCPFH0SJ6YILXJU

PMID:23955459

Abstract

OBJECTIVES

To assess the association between Rosai-Dorfman disease (RDD) and IgG4-related disease (IgG4-RD).

METHODS

We studied the number of IgG4-positive plasma cells and the IgG4/IgG ratio in 32 biopsy specimens (13 nodal, 19 extranodal) from 29 patients with RDD and compared the findings with those in IgG4-RD of the pancreas and reactive lymph nodes. We also assessed the number of FOXP3-positive regulatory T cells (Tregs) since they were reported to be increased in IgG4-RD.

RESULTS

We found that RDD cases had much lower numbers of IgG4-positive plasma cells and lower IgG4/IgG ratios compared with IgG4-RD but were similar to reactive lymph nodes. Furthermore, RDD had lower numbers of FOXP3-positive Tregs than did IgG4-RD. There were no significant differences in the number of IgG4-positive plasma cells and the IgG4/IgG ratio between the nodal and extranodal RDD cases.

CONCLUSIONS

Our study suggests that RDD does not belong in the spectrum of IgG4-RD.

摘要

目的

评估 Rosai-Dorfman 病（RDD）与 IgG4 相关疾病（IgG4-RD）之间的关联。

方法

我们研究了 29 例 RDD 患者的 32 份活检标本（13 份淋巴结，19 份结外）中 IgG4 阳性浆细胞的数量和 IgG4/IgG 比值，并将这些结果与 IgG4-RD 胰腺和反应性淋巴结进行了比较。我们还评估了 FOXP3 阳性调节性 T 细胞（Treg）的数量，因为有报道称 IgG4-RD 中 Treg 数量增加。