Inserm, Center for Research in Epidemiology and Population Health (CESP), U1018, Respiratory and Environmental Epidemiology Team, F-94807, Villejuif, France; Univ Paris-Sud, UMRS 1018, F-94807, Villejuif, France.
Am J Ind Med. 2014 Mar;57(3):303-11. doi: 10.1002/ajim.22244. Epub 2013 Aug 19.
We aimed to assess the associations between occupational exposure to cleaning products, a gender-related exposure, and asthma characteristics, considering clinical, immunological and inflammatory aspects.
Analyses were conducted in 391 women (73 with adult-onset asthma) from the follow-up of the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Occupational exposure to cleaning/disinfecting products was estimated using the asthma-specific job-exposure-matrix (44 women exposed).
Occupational exposures were associated with more symptomatic asthma (odds ratio (95% CI): 2.8(1.2-6.4)) and severe asthma (5.1(1.7-15.3)). An association was suggested for poorly controlled asthma (2.2(0.9-5.5)). Associations were observed for asthma without positive skin prick test (3.0(1.1-8.3)), with a low IgE level (2.8(1.2-6.2)), and with a low eosinophil count (3.2(1.5-7.1)).
Results strengthen the evidence of a deleterious role of cleaning products in asthma and are consistent with the hypothesis of non-allergic mechanisms in relation to workplace cleaning exposures.
我们旨在评估职业暴露于清洁产品（一种与性别相关的暴露）与哮喘特征之间的关联，同时考虑临床、免疫和炎症方面。
在哮喘遗传学和环境研究（EGEA）的随访中，对 391 名女性（73 名患有成年起病哮喘）进行了分析。使用哮喘特异性工作场所暴露矩阵（44 名暴露于清洁/消毒剂的女性）来评估职业暴露于清洁产品的情况。
职业暴露与更多的症状性哮喘（比值比（95%可信区间）：2.8（1.2-6.4））和严重哮喘（5.1（1.7-15.3））相关。同时也提示与控制不佳的哮喘（2.2（0.9-5.5））相关。在无阳性皮肤点刺试验的哮喘（3.0（1.1-8.3））、低 IgE 水平（2.8（1.2-6.2））和低嗜酸性粒细胞计数（3.2（1.5-7.1））中也观察到了关联。
这些结果加强了清洁产品对哮喘有不良影响的证据，并与与工作场所清洁暴露有关的非过敏性机制的假设一致。
