Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW (UK); Department of Chemical Sciences, Tezpur University, Napaam, Tezpur-784 028, Assam (India).
Angew Chem Int Ed Engl. 2013 Sep 27;52(40):10541-4. doi: 10.1002/anie.201302532. Epub 2013 Aug 16.
AFM of cocrystals: Atomic force microscopy can be used to observe phase changes at crystal surfaces where the transformation is accompanied by a change in the spacing between layers of molecules. The conversion of a metastable polymorph of the caffeine-glutaric acid cocrystal into the thermodynamically stable form was analyzed continuously in situ using intermittent-contact-mode atomic force microscopy.
原子力显微镜可用于观察晶体表面的相变化，其中相变伴随着分子层之间间距的变化。使用间歇接触模式原子力显微镜连续原位分析了咖啡因-戊二酸共晶的亚稳多晶型向热力学稳定形式的转化。
