Weintraub Adi Y, Aricha-Tamir Barak, Steiner Naama, Hamou Bat-El, Baron Joel, Hershkovitz Reli
Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences , Ben-Gurion University of the Negev, Beer Sheva , Israel.
Hypertens Pregnancy. 2013 Nov;32(4):450-8. doi: 10.3109/10641955.2013.827204. Epub 2013 Aug 19.
To evaluate postpartum uterine artery (UtA) velocimetry in patients following severe preeclampsia (PET) as compared with normotensive controls.
Postpartum UtA velocimetry was obtained prospectively during the early postpartum period. The right and left UtA pulsatility index (PI) was measured and the presence of an early diastolic notch was noted. For categorical variables, the χ2 test or Fisher exact was used as appropriate and for continuous variables the t-test was used. The p value <0.05 was considered statistically significant.
Thirty-one patients following severe PET and 52 normotensive controls were included in the study. Following severe PET, higher rates of intrauterine growth restriction, cesarean delivery, preterm delivery and accordingly lower neonatal birth weight were noted. Postpartum UtA velocimetry measurements were performed on average 51.2 h after delivery (range 8-169). Right and left UtA PI was comparable between patients following severe PET and controls. The presence of unilateral and bilateral early diastolic notches were significantly higher in patients following severe PET.
The pathophysiology of uterine involution and the physiologic return of the uterine arteries to the non-pregnant state may be different following severe PET.
评估重度子痫前期（PET）患者产后子宫动脉（UtA）血流速度测定情况，并与血压正常的对照组进行比较。
前瞻性地在产后早期获取产后UtA血流速度测定数据。测量左右UtA搏动指数（PI），并记录舒张早期切迹的存在情况。对于分类变量，酌情使用χ2检验或Fisher精确检验，对于连续变量使用t检验。p值<0.05被认为具有统计学意义。
本研究纳入了31例重度PET患者和52例血压正常的对照组。重度PET后，宫内生长受限、剖宫产、早产发生率较高，相应地新生儿出生体重较低。产后UtA血流速度测定平均在分娩后51.2小时进行（范围8 - 169小时）。重度PET患者与对照组之间左右UtA PI相当。重度PET患者中单侧和双侧舒张早期切迹的出现率显著更高。
重度PET后子宫复旧的病理生理学以及子宫动脉恢复到非妊娠状态的生理过程可能有所不同。
